부항만 떳는데 코로나 백신 효과 100배 증가↑

부항만 떳는데 코로나 백신 효과 100배 증가↑: 2021.11.11 13:47 입력

부항만 떳는데 코로나 백신 효과 100배 증가↑   <o:p></o:p>   한미(韓美) 연구진은 한방치료법 중 하나인 부항(附缸)이 코로나 백신 효과를 높이는데 100배 효과를 얻을 수 있다는 연구 결과를 냈다. 지난 25일 국제학술지 ‘사이언스 어드밴스’에서 국내 진원생명과학의 조엘 매슬로우 박사 공동 연구진과 미국 럿거스대 하오 린 교수는 “DNA 기반의 코로나 백신을 접종한 뒤 부항 치료처럼 피부에 음압을 걸면 면역반응이 훨씬 강해지는 것을 동물실험으로 확인했다”고 밝혔다.   <o:p></o:p>    이 연구는 실험용 쥐에게 코로나 백신을 주사하는 것이다. 이 백신은 코로나 바이러스의 스파이크(돌기) 단백질을 만드는 DNA를 인체에 전달해 중화항체를 유도하는 원리이다. 현재 접종 중인 미국 화이자와 모더나의 mRNA 백신은 핵 바깥쪽 세포질에서 작용하는 방면, DNA 백신은 세포핵으로 들어가는 방식이다.        ▶쥐에게 DNA 백신접종 후 부항 치료 결과  <div style="mso-pagination: none; mso-padding-alt: 0pt 0pt 0pt 0pt;"> <table class="__se_tbl_ext" align="center" id="news_image" style="border: 1px solid rgb(210, 210, 210); border-image: none; margin-top: 15px; margin-bottom: 15px;" border="0" cellspacing="0" cellpaddin="0"><tbody><tr><td><div style="margin: 8px;"><img width="458" align="absmiddle" src="http://unmenews.com/PEG/16366056882766.png"></div></td></tr></tbody></table> <o:p></o:p></div>    쥐에게 DNA 백신 접종을 한 다음에 쥐의 피부에 작은 유리컵을 대고 30초간 펌프로 빨아들였다(A). 이는 부항 치료와 같은 효과를 냈다(C). 그 결과 백신만 맞을 때와 달리 항체가 100배나 더 많이 생성됨을 알 수 있었다. 연구를 통해 연구진은 “부항이 피부를 수축 및 이완시켜 세포가 바깥쪽의 입자를 더 많이 받아들이도록 하는 것으로 보인다“고 밝혔다. 또한 동일한 방법으로 같은 부항을 연구진 피부에 직접 실험해봤으나 통증이 없었다고 밝혔다.    ▶쥐에게 코로나 백신접종 후    <div style="mso-pagination: none; mso-padding-alt: 0pt 0pt 0pt 0pt;"><table class="__se_tbl_ext" align="center" id="news_image" style="border: 1px solid rgb(210, 210, 210); border-image: none; margin-top: 15px; margin-bottom: 15px;" border="0" cellspacing="0" cellpaddin="0"><tbody><tr><td><div style="margin: 8px;"><img width="532" align="absmiddle" src="http://unmenews.com/PEG/16366057157096.jpg"></div><div align="center" style="margin: 8px; text-align: center;">부항의 유무에 따른 형광 유전자 발현정도 비교</div></td></tr></tbody></table>     <o:p></o:p></div>    위 사진은 쥐에게 DNA 코로나 백신만 주사한 경우(D)와 백신 접종 후 부항 치료를 한 경우(E)를 시간(1-48시간)에 따라 비교한 사진이다. 형광이 잘 보일수록 DNA 백신이 더 잘 전달된 것이다. 백신 접종 후 부항 치료를 하면 백신만 주사한 경우보다 백신이 더 많이 전달됨을 알 수 있다. <div class="hwp_editor_board_content" id="hwpEditorBoardContent" data-jsonlen="320821" data-hjsonver="1.0"><!--[data-hwpjson]{
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"t": " 한미(韓美) 연구진은 한방치료법 중 하나인 부항(附缸)이 코로나 백신 효과를 높이는데 100배 효과를 얻을 수 있다는 연구 결과를 냈다. 지난 25일 국제학술지 ‘사이언스 어드밴스’에서 국내 진원생명과학의 조엘 매슬로우 박사 공동 연구진과 미국 럿거스대 하오 린 교수는 “DNA 기반의 코로나 백신을 접종한 뒤 부항 치료처럼 피부에 음압을 걸면 면역반응이 훨씬 강해지는 것을 동물실험으로 확인했다”고 밝혔다. "
}
]
}
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{
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{
"t": " 이 연구는 실험용 쥐에게 코로나 백신을 주사하는 것이다. 이 백신은 코로나 바이러스의 스파이크(돌기) 단백질을 만드는 DNA를 인체에 전달해 중화항체를 유도하는 원리이다. 현재 접종 중인 미국 화이자와 모더나의 mRNA 백신은 핵 바깥쪽 세포질에서 작용하는 방면, DNA 백신은 세포핵으로 들어가는 방식이다. "
}
]
}
]
},
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{
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},
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"ru": [
{
"cp": "01D7D6B35FBED17000000022",
"ch": [
{
"t": " ▶쥐에게 DNA 백신접종 후 부항 치료 결과 "
}
]
}
]
},
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"si": "01D7D6B35FBED17000000028",
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"ru": [
{
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"ch": [
{
"t": " "
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,
{
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{
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},
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"id": -2147483648,
"pp": "01D7D6B35FBED17000000027",
"si": "01D7D6B35FBED17000000028",
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"t": " "
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},
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"id": -2147483648,
"pp": "01D7D6B35FBED17000000027",
"si": "01D7D6B35FBED17000000028",
"bf": 0,
"ru": [
{
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},
"01D7D6B35FBED17000000014": {
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"id": -2147483648,
"pp": "01D7D6B35FBED17000000027",
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"bf": 0,
"ru": [
{
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"ch": [
{
"t": " 쥐에게 DNA 백신 접종을 한 다음에 쥐의 피부에 작은 유리컵을 대고 30초간 펌프로 빨아들였다(A). 이는 부항 치료와 같은 효과를 냈다(C). 그 결과 "
}
]
}
,
{
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{
"t": "백신만 맞을 때와 달리 항체가 100배나 더 많이 생성됨"
}
]
}
,
{
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{
"t": "을 알 수 있었다. 연구를 통해 연구진은 “부항이 피부를 수축 및 이완시켜 세포가 바깥쪽의 입자를 더 많이 받아들이도록 하는 것으로 보인다“고 밝혔다. 또한 동일한 방법으로 같은 부항을 연구진 피부에 직접 실험해봤으나 통증이 없었다고 밝혔다."
}
]
}
]
},
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"bf": 0,
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"id": -2147483648,
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"ru": [
{
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"ch": [
{
"t": " ▶쥐에게 코로나 백신접종 후 "
}
]
}
]
},
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"bf": 0,
"ru": [
{
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"ch": [
{
"t": " 부항의 유무에 따른 형광 유전자 발현정도 비교 "
}
]
}
]
},
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{
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{
"t": " 위 사진은 쥐에게 DNA 코로나 백신만 주사한 경우(D)와 백신 접종 후 부항 치료를 한 경우(E)를 시간(1-48시간)에 따라 비교한 사진이다. 형광이 잘 보일수록 DNA 백신이 더 잘 전달된 것이다. 백신 접종 후 부항 치료를 하면 백신만 주사한 경우보다 백신이 더 많이 전달됨을 알 수 있다. "
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